Our Innovation

At HealthSpan Research, our focus is developing small extracellular vesicles (exosomes) as a therapeutic modality in the treatment of Alzheimer's Disease (AD). These naturally occurring nanoparticles, ranging from 30-150nm in diameter, are isolated from the plasma of young, healthy donors aged 18-25 years. Our proprietary large-scale purification technology efficiently processes multiple liters of plasma or serum to obtain highly purified, native exosomes. Our gene expression pilot studies have demonstrated that these young plasma-derived exosomes possess significant therapeutic potential. These vesicles contain naturally occurring bioactive molecules, including proteins, miRNAs, and growth factors that show promise in modulating key pathological processes in AD. Previous research has established that plasma-derived exosomes can effectively cross the blood-brain barrier, making them excellent candidates for CNS therapeutic delivery. This therapeutic potential combined with the scalability of our proprietary purification process,, ensures consistent preparation of these therapeutic candidates while maintaining their natural biological properties.

At HealthSpan Research LLC, we have assembled a team of talented and dedicated professionals who are passionate about improving healthcare through biotechnology. Our team includes scientists, researchers, and business professionals, all of whom bring unique skills and perspectives to our work.

 Alzheimer’s Disease affects over 50 million people worldwide with one person being diagnosed with the disease every 3 seconds worldwide. No effective treatments are currently available despite billions of dollars spent on research. Existing approaches focus on amyloid-beta plaques, a strategy with extremely limited success in clinical trials. Patients and families face limited options, increasing emotional and financial burdens on healthcare systems globally.  At HealthSpan Research, we are pioneering a revolutionary approach to Alzheimer’s treatment by harnessing the therapeutic potential of naturally occurring exosomes.